Survival Outcome of Squamous Cell Carcinoma Arising from Sinonasal Inverted Papilloma

Survival Outcome of Squamous Cell Carcinoma Arising from Sinonasal Inverted Papilloma

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Background: Sinonasal inverted papilloma (IP) is a rare benign tumor of the nasal cavities and paranasal sinuses.It is destructive or bone-remodeling, tends to recur after surgical resection, and has a significant malignant potential.The present study aimed to perform a retrospective analysis of patients with squamous cell thy art is murder oslo carcinoma (SCC) arising from IP, including characteristics, survival outcome, and predictors of associated malignancy.Methods: The medical records of 213 patients diagnosed with IP from January 1970 to January 2014 were retrospectively reviewed.

Eighty-seven patients were diagnosed with SCC/IP; their clinical characteristics, treatments, and survival outcomes were analyzed.Results: Of the 87 patients with SCC/IP, the 5- and 10-year overall survival outcomes were 39.6% and 31.8%, respectively.

Twenty-nine of these patients received surgery and 58 received combined surgery and radiation.Of the patients with stages III-IV, the 5-year survival rate was 30.7% for those treated with surgery only and 39.9% for those given the combination treatment (P = 0.

849).Factors associated with significantly poor prognosis were advanced-stage, metachronous tumors, or with cranial base and orbit invasion.Age, synchronous or metachronous tumors, and pathological stage were independent risk factors for mortality, shown by multivariate analysis.Conclusion: Patients with SCC/IP had low overall survival outcomes.

Advanced age, stage, and metachronous tumors are the main gemplers free shipping factors affecting prognosis.Treatment planning should consider high-risk factors to improve survival outcome.